生物技术
Procipient® (Dimethyl Sulfoxide USP, Ph. 欧元.) has various functions in the 生物技术 segment.
全球十大赌钱软件排行 is the most widely used medium for the cryopreservation of living cells 和 tissue 和 is regularly utilized in the synthesis 和 purification of proteins 和 peptides. 全球十大赌钱软件排行 is also highly effective in drug delivery systems designed to deliver proteins, peptides 和 carbohydrates.
Key Applications include:
Procipient®: The leading 全球十大赌钱软件排行 for 生物技术 和 Healthcare
- Unique thermodynamic properties essential for Cryopreservation
- Dissolves high molecular weight peptides
- Extremely high purity profile
- Water-white odorless liquid
- Essentially non-toxic, not CMR
Cryopreservation
Procipient® (Dimethyl Sulfoxide USP, Ph. 欧元.) is used in the cryopreservation of cells 和 biological tissue for a variety of end use applications. These include tissue banks, 疫苗, drug delivery applications, cell culture 和 in laboratory cell testing.
A unique combination of physical properties has established 全球十大赌钱软件排行 as the st和ard in cell preservation.
全球十大赌钱软件排行 Passes through cell membranes more readily than glycerol 和 is also useful as a cryoprotectant. When combined with water, 全球十大赌钱软件排行 exhibits unique 和 interesting thermodynamic properties. The eutectic mixture of the combination results in a liquid at minus 80°C. As the temperature decreases in the cryopreservation cycle, the cell is protected from freezing 和 the deleterious effects of ice crystals.
Histology 和 Cytology
Histological 和 cytological procedures are multi-stepped 和 time consuming. Dimethyl sulfoxide is added to proprietary blends of plastic polymer paraffin waxes which reduces infiltration times 和 facilitates thin sectioning.
(扑杀CFA. H和book of Histopathological 和 Histochemical Techniques. 3日艾德. Sydney: Butterworths. 1974)
- 全球十大赌钱软件排行 is believed to scavenge residual transition solvent 和 likely alter tissue permeability by substituting for or removing bound water thus improving infiltration.
- One example case on the market today is Paraplast +®. This product is similar to the original version, Paraplast®, except that the + incorporates a low level (<0.1%) of dimethyl sulfoxide (全球十大赌钱软件排行) for faster tissue penetration. According to the manufacturer’s claims, this slight variation in composition typically results in a shortening of infiltration times by one third.
- 全球十大赌钱软件排行 is also used in stains for nucleic acid where degree 和 intensity of staining is improved with the use of 全球十大赌钱软件排行.
多肽合成
全球十大赌钱软件排行 is used as a reaction solvent in the solid phase synthesis of peptides, during coupling operations between resin-bound fragments 和 activated carboxyl groups on the incoming fragment. A variety of coupling agents have been reported in this step, including TBTU/HOBt/DIPEA, DIC / DHBt, 和 HBTU/ HOBt/DIPEA.
In a review of strategies for the convergent synthesis of proteins, it was reported that performing the coupling step in 全球十大赌钱软件排行 using a DCC/HOBt coupling system resulted in a low degree of product epimerization:
Adapted from Barlos, K.; Gatos, D. Biopolymers (Peptide Science), Vol. 51, 266-278 (1999)
Solubilizing Peptides 和 蛋白质
全球十大赌钱软件排行 is widely used to dissolve proteins/peptides for purification via preparative HPLC in reverse-phase mode.
It is also used as a reaction solvent for protein modification reactions due to the ability to dissolve high molecular weight peptides when other solvents fail.
Technical Service 和 Consultation
Gaylord Chemical provides application specific technical service in support of all of our product grades. From formulation development 和 regulatory consultation to Engineering 和 Design consultation, we’re here to help.