全球十大赌钱软件排行 as the carbon source in transition-metal-free α-Csp3-H methylenation
The ability to make the C=C bond at a targeted position has always been of high interest to synthetic chemists. 最近，郭等人. reported a method by which to activate a hydrogen at the alpha position of a ketone in order to make a new C=C bond at that position (Figure 1).他们的[…]
全球十大赌钱软件排行 as the carbon source for sp3 C-H olefination
The examples of dimethyl sulfoxide acting as a one carbon source for methylenation reactions continue to grow. (See recent 合成的角落 posts from January, 2018—“全球十大赌钱软件排行 as the carbon source in transition-metal-free α-Csp3-H methenylation” and March, 2018—“全球十大赌钱软件排行 as a one carbon source in the transition-metal-free synthesis of quinolones.)最近，Namitharan等人. 全球十大赌钱软件排行合成的报道[…]
CuI/全球十大赌钱软件排行-mediated synthesis of 3-sulfonyl dihydrofurans
Five-membered rings containing oxygen are common and recurring motifs in biologically-active compounds. 因此, the development of routes to synthesize these ring systems is of great interest. 最近，Chang等人. developed a one-pot (3 + 2) annulation method to synthesize 3-sulfonyl dihydrofurans (Equation 1).1 This method uses readily-available and relatively inexpensive CuI and 全球十大赌钱软件排行 to give […]
Visible Light Promoted Synthesis of Indoles in 全球十大赌钱软件排行
The indole ring is widely found in pharmaceutical compounds, agrochemicals, and natural products. 因此, methods to produce this heterocycle are important. Traditional methods to synthesize the indole ring often suffer from the requirement of exotic starting materials, 功能群耐受性差, and from the generation of significant amounts of undesirable byproducts. 因此，更环保，更…
全球十大赌钱软件排行 as the Solvent for Cu(I)-Catalyzed Reactions: The Synthesis of Pyrrole Derivatives
最近, Zhao’s group reported on the oxidative cyclization of maleimides with amines and alkyne esters to form pyrrole and dihydropyrrole derivatives (Figure 1).1 The importance of these five-membered nitrogen-containing heterocyclic compounds cannot be overstated, as they are common in biologically- and pharmaceutically-active compounds. 因此, the chemical literature is filled with examples of routes to form these […]
Synthesis of β-Amino Alcohol Derivatives through a Photo-Induced Reaction in 全球十大赌钱软件排行
Synthetic routes to β-amino alcohols and their derivatives are extremely important as these compounds are widespread in natural products, 药品, 和农用化学品. In 2018, Yu’s group published an interesting photoredox-induced radical relay method in 全球十大赌钱软件排行 to synthesize functionalized β-amino alcohol derivatives.1 Unlike other established methods to simultaneously construct a C-N and a C-O bond across the carbon-carbon […]
全球十大赌钱软件排行 as the Oxidant in the α-Sulfenylation of Unsaturated Ketones
The number of reactions continues to grow where the interaction of 全球十大赌钱软件排行 and iodine result in the functionalization of a C–H bond. (参见7月28日的合成角帖子 & March 29, 2017 and October 29, 2016 for recent examples.) An example published in 2018 by the Prabhu group introduces the completely regioselective αʹ-sulfenylation of an α,β不饱和[…]
全球十大赌钱软件排行-I2-Promoted Insertion of Isocyanide into the N–H Bond of Amines: Synthesis of Ureas
Metal-catalyzed insertion reactions of isocyanides into amines have been developed with the ultimate goal of synthesizing nitrogen-containing heterocycles. These routes have had problems in that isocyanides often strongly coordinate to metal catalysts, and they often undergo polymerization under these conditions.1 Because of this, there is interest in developing metal-free methods. 无金属插入[…]
全球十大赌钱软件排行/I2: Simple and Green Syntheses of Imidazoles
Imidazoles are crucial building blocks for many 药品 and agrichemicals. Trisubstituted imidazoles are particularly important. 因此, several methods have been developed to synthesize these structural units; however, these methods generally have several drawbacks, including the need for complex and harsh reaction conditions and toxic transition metal reagents. Additionally, they sometimes produce many side products. 因此,[…]
Visible-Light-Mediated Synthesis of γ-Ketoesters in 全球十大赌钱软件排行
γ-Ketoesters are common synthetic building blocks. 因此, diverse synthetic methods have been developed to prepare these compounds. 最近, the Liu group reported a visible-light-mediated method, 使用紧凑型荧光灯(CFL), where the oxidative coupling of readily available vinylarenes and bromocarboxylates, 然后是全球十大赌钱软件排行中的科恩布卢姆型氧化, furnishes the desired γ-ketoester (equation in Table 1, […]